Polygenic risk score for predicting weight loss after bariatric surgery.

ABSTRACT:

Background

The extent of weight loss among patients undergoing bariatric surgery is highly variable. Herein, we tested the contribution of genetic background to such interindividual variability after biliopancreatic diversion with duodenal switch.

Methods

Percentage of excess body weight loss (%EBWL) was monitored in 865 patients over a period of 48 months after bariatric surgery, and two polygenic risk scores were constructed with 186 and 11 (PRS186 and PRS11) single nucleotide polymorphisms previously associated with body mass index (BMI).

Results

The accuracy of the %EBWL logistic prediction model - including initial BMI, age, sex, and surgery modality, and assessed as the area under the receiver operating characteristics (ROC) curve adjusted for optimism (AUCadj =

SUBMITTER: de Toro-Martin J 

PROVIDER: S-EPMC6171810 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature