Development of standard clinical endpoints for use in dengue interventional trials.

ABSTRACT: Dengue is a major public health problem worldwide. Although several drug candidates have been evaluated in randomized controlled trials, none has been effective and at present, early recognition of severe dengue and timely supportive care are used to reduce mortality. While the first dengue vaccine was recently licensed, and several other candidates are in late stage clinical trials, future decisions regarding widespread deployment of vaccines and/or therapeutics will require evidence of product safety, efficacy and effectiveness. Standard, quantifiable clinical endpoints are needed to ensure reproducibility and comparability of research findings. To address this need, we established a working group of dengue researchers and public health specialists to develop standardized endpoints and w

SUBMITTER: Tomashek KM 

PROVIDER: S-EPMC6171842 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature