Proteome-scale relationships between local amino acid composition and protein fates and functions.

ABSTRACT: Proteins with low-complexity domains continue to emerge as key players in both normal and pathological cellular processes. Although low-complexity domains are often grouped into a single class, individual low-complexity domains can differ substantially with respect to amino acid composition. These differences may strongly influence the physical properties, cellular regulation, and molecular functions of low-complexity domains. Therefore, we developed a bioinformatic approach to explore relationships between amino acid composition, protein metabolism, and protein function. We find that local compositional enrichment within protein sequences is associated with differences in translation efficiency, abundance, half-life, protein-protein interaction promiscuity, subcellular localization, and m

SUBMITTER: Cascarina SM 

PROVIDER: S-EPMC6171957 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature