Integrated fluorescent cytology with nano-biologics in peritoneally disseminated gastric cancer.

ABSTRACT: Gastric cancer patients positive for peritoneal cytology are at increased risk of tumor recurrence, but although a certain proportion of cytology-positive patients relapse rapidly with aggressive progression, others survive longer with conventional chemotherapies. This heterogeneity makes it difficult to stratify patients for more intensive therapy and poses a substantial challenge for the implementation of precision medicine. We developed a new approach to identify biologically malignant subpopulations in cytology-positive gastric cancer patients, using a green fluorescent protein (GFP)-expressing attenuated adenovirus in which the telomerase promoter regulates viral replication (TelomeScan, OBP-401). The fluorescence emitted from TelomeScan-positive cells was successfully quantified usin

SUBMITTER: Watanabe M 

PROVIDER: S-EPMC6172043 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature