TRIM44 promotes human esophageal cancer progression via the AKT/mTOR pathway.

ABSTRACT: Aberrant expression of TRIM-containing protein 44 (TRIM44) acts as a promoter in multiple cancers. Here, we investigated the biological functions and clinical significance of TRIM44 in human esophageal cancer (HEC). TRIM44 expression was significantly higher in HEC tissues than corresponding normal tissues at both the mRNA (2.42 ± 0.52 vs 0.99 ± 0.25) and protein (1.01 ± 0.27 vs 0.30 ± 0.13) levels. Patients with high TRIM44 expression showed poor differentiation (P = 1.39 × 10^-5 ), advanced TNM stage (P = 3.87 × 10^-4 ) and, most importantly, significantly poorer prognosis (P = 2.80 × 10^-5 ). TRIM44 played a crucial role in epithelial mesenchymal transition (EMT). A significant correlation was observed between TRIM44 and Ki67 expression. We demonstrated tha

SUBMITTER: Xiong D 

PROVIDER: S-EPMC6172051 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature