Relationship between permeability and diffusivity in polyethylene glycol hydrogels.

ABSTRACT: The transport properties of hydrogels largely affect their performance in biomedical applications ranging from cell culture scaffolds to drug delivery systems. Solutes can move through the polymer mesh as a result of concentration gradients in the interstitial fluid or pressure gradients that move the fluid and solutes simultaneously. The relationship between the two modalities of transport in hydrogels can provide insight for the design of materials that can function effectively in the dynamic conditions experienced in vitro and in vivo, yet this correlation has not been previously elucidated. Here, fluorescence recovery after photobleaching (FRAP) is used to measure the diffusivity of dextran molecules of different size within polyethylene glycol hydrogels. Spherical indent

SUBMITTER: Offeddu GS 

PROVIDER: S-EPMC6172138 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature