MiR-486-5p Downregulation Marks an Early Event in Colorectal Carcinogenesis.

ABSTRACT:

Background

MicroRNAs are dysregulated in colorectal cancer and subsets correlated with advanced tumor stage and metastasis. Data are lacking on microRNA dysregulation from early to late-stage disease.

Objective

The purpose of this study was to identify a microRNA signature associated with the primary tumor and metastatic site in stage IV disease and to examine whether the signature is evident in earlier stages.

Design

A microRNA profile was generated and then explored in normal colon tissue (n = 5), early stage (stage I and II; n = 10), and late-stage (stage III and IV; n = 14) colorectal primary tumors via polymerase chain reaction to delineate molecular events that may promote colorectal carcinogenesis.

Setting

Genome-wide microRNA expression profiling was pe

SUBMITTER: Kelley KA 

PROVIDER: S-EPMC6172144 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature