Epithelial membrane protein 1 promotes tumor metastasis by enhancing cell migration via copine-III and Rac1.

ABSTRACT: Tumor metastasis is the most common cause of cancer death. Elucidation of the mechanism of tumor metastasis is therefore important in the development of novel, effective anti-cancer therapies to reduce cancer mortality. Interaction between cancer cells and surrounding stromal cells in the tumor microenvironment is a key factor in tumor metastasis. Using a co-culture assay system with human prostate cancer LNCaP cells and primary human prostate stromal cells, we identified epithelial membrane protein 1 (EMP1) as a gene with elevated expression in the cancer cells. The orthotopic injection of LNCaP cells overexpressing EMP1 (EMP1-LNCaP cells) into the prostate of nude mice induced lymph node and lung metastases, while that of control LNCaP cells did not. EMP1-LNCaP cells had higher cell moti

SUBMITTER: Ahmat Amin MKB 

PROVIDER: S-EPMC6172191 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature