Genome-wide association study reveals novel genetic locus associated with intra-individual variability in response time.

ABSTRACT: Intra-individual response time variability (IIRTV) is proposed as a viable endophenotype for many psychiatric disorders, particularly attention-deficit hyperactivity disorder (ADHD). Here we assessed whether IIRTV was associated with common DNA variation genome-wide and whether IIRTV mediated the relationship between any associated loci and self-reported ADHD symptoms. A final data set from 857 Australian young adults (489 females and 368 males; M_age = 22.14 years, SD_age = 4.82 years) who completed five response time tasks and self-reported symptoms of ADHD using the Conners' Adult ADHD Rating Scale was used. Principal components analysis (PCA) on these response time measures (standard deviation of reaction times and the intra-individual coefficient of variation) prod

SUBMITTER: Pinar A 

PROVIDER: S-EPMC6172232 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature