Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese.

ABSTRACT: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb), and remains a leading public health problem. Previous studies have identified host genetic factors that contribute to Mtb infection outcomes. However, much of the heritability in TB remains unaccounted for and additional susceptibility loci most likely exist. We perform a multistage genome-wide association study on 2949 pulmonary TB patients and 5090 healthy controls (833 cases and 1220 controls were genome-wide genotyped) from Han Chinese population. We discover two risk loci: 14q24.3 (rs12437118, P_combined = 1.72 × 10^-11, OR = 1.277, ESRRB) and 20p13 (rs6114027, P_combined = 2.37 × 10^-11, OR = 1.339, TGM6). Moreover, we determine that the rs6114027 risk allele

SUBMITTER: Zheng R 

PROVIDER: S-EPMC6172286 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature