Bioinformatics analyses of significant genes, related pathways and candidate prognostic biomarkers in glioblastoma.

ABSTRACT: Glioblastoma (GBM) is the most common type of malignant tumor of the central nervous system. The prognosis of patients with GBM is very poor, with a survival time of ~15 months. GBM is highly heterogeneous and highly aggressive. Surgical removal of intracranial tumors does provide a good advantage for patients as there is a high rate of recurrence. The understanding of this type of cancer needs to be strengthened, and the aim of the present study was to identify gene signatures present in GBM and uncover their potential mechanisms. The gene expression profiles of GSE15824 and GSE51062 were downloaded from the Gene Expression Omnibus database. Normalization of the data from primary GBM samples and normal samples in the two databases was conducted using R software. Then, joint analysis of th

SUBMITTER: Zhou L 

PROVIDER: S-EPMC6172372 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature