Zebrafish Recoverin Isoforms Display Differences in Calcium Switch Mechanisms.

ABSTRACT: Primary steps in vertebrate vision occur in rod and cone cells of the retina and require precise molecular switches in excitation, recovery, and adaptation. In particular, recovery of the photoresponse and light adaptation processes are under control of neuronal Ca²⁺ sensor (NCS) proteins. Among them, the Ca²⁺ sensor recoverin undergoes a pronounced Ca²⁺-dependent conformational change, a prototypical so-called Ca²⁺-myristoyl switch, which allows selective targeting of G protein-coupled receptor kinase. Zebrafish (Danio rerio) has gained attention as a model organism in vision research. It expresses four different recoverin isoforms (zRec1a, zRec1b, zRec2a, and zRec2b) that are orthologs to the one known mammalian variant. The expression p

SUBMITTER: Elbers D 

PROVIDER: S-EPMC6172410 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature