Identification of nine novel loci related to hematological traits in a Japanese population.

ABSTRACT: Recent genome-wide association studies have identified various genetic variants associated with hematological traits. Although it is possible that quantitative data of hematological traits are varied among the years examined, conventional genome-wide association studies have been conducted in a cross-sectional manner that measures traits at a single point in time. To address this issue, we have traced blood profiles in 4,884 Japanese individuals who underwent annual health check-ups for several years. In the present study, longitudinal exome-wide association studies were conducted to identify genetic variants related to 13 hematological phenotypes. The generalized estimating equation model showed that a total of 67 single nucleotide polymorphisms (SNPs) were significantly [false discovery

SUBMITTER: Yasukochi Y 

PROVIDER: S-EPMC6172615 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature