Impact of acute exposure to cigarette smoke on airway gene expression.

ABSTRACT:

Background

Understanding effects of acute smoke exposure (ASE) on airway epithelial gene expression and their relationship with the effects of chronic smoke exposure may provide biological insights into the development of smoking-related respiratory diseases.

Methods

Bronchial airway epithelial cell brushings were collected from 63 individuals without recent cigarette smoke exposure and before and 24 h after smoking three cigarettes. RNA from these samples was profiled on Affymetrix Human Gene 1.0 ST microarrays.

Results

We identified 91 genes differentially expressed 24 h after ASE (false discovery rate < 0.25). ASE induced genes involved in xenobiotic metabolism, oxidative stress, and inflammation and repressed genes related to cilium morphogenesis and cell cycle. W

SUBMITTER: Billatos E 

PROVIDER: S-EPMC6172616 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature