Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer.

ABSTRACT:

Background

The recurrence score based on the 21-gene breast cancer assay predicts chemotherapy benefit if it is high and a low risk of recurrence in the absence of chemotherapy if it is low; however, there is uncertainty about the benefit of chemotherapy for most patients, who have a midrange score.

Methods

We performed a prospective trial involving 10,273 women with hormone-receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative, axillary node-negative breast cancer. Of the 9719 eligible patients with follow-up information, 6711 (69%) had a midrange recurrence score of 11 to 25 and were randomly assigned to receive either chemoendocrine therapy or endocrine therapy alone. The trial was designed to show noninferiority of endocrine therapy alone for invasi

SUBMITTER: Sparano JA 

PROVIDER: S-EPMC6172658 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature