Assessing the bioaccumulation potential of ionizable organic compounds: Current knowledge and research priorities.

ABSTRACT: The objective of the present study was to review the current knowledge regarding the bioaccumulation potential of ionizable organic compounds (IOCs), with a focus on the availability of empirical data for fish. Aspects of the bioaccumulation potential of IOCs in fish that can be characterized relatively well include the pH dependence of gill uptake and elimination, uptake in the gut, and sorption to phospholipids (membrane-water partitioning). Key challenges include the lack of empirical data for biotransformation and binding in plasma. Fish possess a diverse array of proteins that may transport IOCs across cell membranes. Except in a few cases, however, the significance of this transport for uptake and accumulation of environmental contaminants is unknown. Two case studies are presented.

SUBMITTER: Armitage JM 

PROVIDER: S-EPMC6172661 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature