Common and Rare Genetic Risk Factors Converge in Protein Interaction Networks Underlying Schizophrenia.

ABSTRACT: Hundreds of genomic loci have been identified with the recent advances of schizophrenia in genome-wide association studies (GWAS) and sequencing studies. However, the functional interactions among those genes remain largely unknown. We developed a network-based approach to integrate multiple genetic risk factors, which lead to the discovery of new susceptibility genes and causal sub-networks, or pathways in schizophrenia. We identified significantly and consistently over-represented pathways in the largest schizophrenia GWA studies, which are highly relevant to synaptic plasticity, neural development and signaling transduction, such as long-term potentiation, neurotrophin signaling pathway, and the ERBB signaling pathway. We also demonstrated that genes targeted by common SNPs are more lik

SUBMITTER: Chang X 

PROVIDER: S-EPMC6172705 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature