Uc.416 + A promotes epithelial-to-mesenchymal transition through miR-153 in renal cell carcinoma.

ABSTRACT:

Background

The transcribed ultraconserved regions (T-UCRs) are a novel class of non-coding RNAs that are absolutely conserved across species and are involved in carcinogenesis in some cancers. However, the expression and biological role of T-UCRs in renal cell carcinoma (RCC) remain poorly understood. This study aimed to examine the expression and functional role of Uc.416 + A and analyze the association between Uc.416 + A and epithelial-to-mesenchymal transition in RCC.

Methods

Expression of Uc.416 + A in 35 RCC tissues, corresponding normal kidney tissues and 13 types of normal tissue samples was determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). We performed a cell growth and migration assay in RCC cell line 786-O transfected with negati

SUBMITTER: Sekino Y 

PROVIDER: S-EPMC6172711 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature