Screening and identification of potential novel biomarker for diagnosis of complicated Plasmodium vivax malaria.

ABSTRACT:

Background

In the recent years Plasmodium vivax has been reported to cause severe infections associated with mortality. Clinical evaluation has limited accuracy for the early identification of the patients progressing towards the fatal condition. Researchers have tried to identify the serum and the plasma-based indicators of the severe malaria. Discovery of MicroRNA (miRNA) has opened up an era of identification of early biomarkers for various infectious and non-infectious diseases. MicroRNAs (miRNA) are the small non-coding RNA molecules of length 19-24 nts and are responsible for the regulation of the majority of human gene expressions at post transcriptional level.

Methods

We identified the differentially expressed miRNAs by microarray and validated the selected miRNAs by

SUBMITTER: Kaur H 

PROVIDER: S-EPMC6172720 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature