Pediatric asthma comprises different phenotypic clusters with unique nasal microbiotas.

ABSTRACT:

Background

Pediatric asthma is the most common chronic childhood disease in the USA, currently affecting ~ 7 million children. This heterogeneous syndrome is thought to encompass various disease phenotypes of clinically observable characteristics, which can be statistically identified by applying clustering approaches to patient clinical information. Extensive evidence has shown that the airway microbiome impacts both clinical heterogeneity and pathogenesis in pediatric asthma. Yet, so far, airway microbiotas have been consistently neglected in the study of asthma phenotypes. Here, we couple extensive clinical information with 16S rRNA high-throughput sequencing to characterize the microbiota of the nasal cavity in 163 children and adolescents clustered into different asthma phenot

SUBMITTER: Perez-Losada M 

PROVIDER: S-EPMC6172741 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature