Disruption of cortical network activity by the general anaesthetic isoflurane.

ABSTRACT:

Background

Actions of general anaesthetics on activity in the cortico-thalamic network likely contribute to loss of consciousness and disconnection from the environment. Previously, we showed that the general anaesthetic isoflurane preferentially suppresses cortically evoked synaptic responses compared with thalamically evoked synaptic responses, but how this differential sensitivity translates into changes in network activity is unclear.

Methods

We investigated isoflurane disruption of spontaneous and stimulus-induced cortical network activity using multichannel recordings in murine auditory thalamo-cortical brain slices.

Results

Under control conditions, afferent stimulation elicited short latency, presumably monosynaptically driven, spiking responses, as well as lo

SUBMITTER: Hentschke H 

PROVIDER: S-EPMC6172964 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature