Visual recognition memory is impaired in rhesus monkeys repeatedly exposed to sevoflurane in infancy.

ABSTRACT:

Background

Experimental studies in animals have shown that exposure to general anaesthesia in infancy can cause loss of cells in the central nervous system and long-term impairments in neurocognitive function. Some human epidemiological studies have shown increased risk of learning disability after repeated anaesthesia exposure in early childhood. Thus, we investigated in a highly translational rhesus monkey model, whether repeated exposure in infancy to the inhalation anaesthetic sevoflurane is associated with impaired visual recognition memory during the first two yr of life.

Methods

Rhesus monkeys of both sexes were exposed to sevoflurane inhalation anaesthesia on approximately postnatal day 7 and then again 14 and 28 days later, for four h each time. Visual recognition m

SUBMITTER: Alvarado MC 

PROVIDER: S-EPMC6172969 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature