Association of intraoperative changes in brain-derived neurotrophic factor and postoperative delirium in older adults.

ABSTRACT:

Background

Delirium is common after surgery, although the aetiology is poorly defined. Brain-derived neurotrophic factor (BDNF) is a neurotrophin important in neurotransmission and neuroplasticity. Decreased levels of BDNF have been associated with poor cognitive outcomes, but few studies have characterized the role of BDNF perioperatively. We hypothesized that intraoperative decreases in BDNF levels are associated with postoperative delirium.

Methods

Patients undergoing spine surgery were enrolled in a prospective cohort study. Plasma BDNF was collected at baseline and at least hourly intraoperatively. Delirium was assessed using rigorous methods, including the Confusion Assessment Method (CAM) and CAM for the intensive care unit. Associations of changes in BDNF and deliriu

SUBMITTER: Wyrobek J 

PROVIDER: S-EPMC6172970 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature