Relation of placental alkaline phosphatase expression in human term placenta with maternal and offspring fat mass.

ABSTRACT:

Introduction

Alkaline phosphatase is implicated in intestinal lipid transport and in the development of obesity. Placental alkaline phosphatase is localised to the microvillous plasma membrane of the placental syncytiotrophoblast at the maternal-fetal interface, but its role is unclear. We investigated the relations of placental alkaline phosphatase activity and mRNA expression with maternal body composition and offspring fat mass in humans.

Methods

Term human placentas from the UK Birthright cohort (n = 52) and the Southampton Women's Survey (SWS) (n = 95) were studied. In the Birthright cohort, alkaline phosphatase activity was measured in placental microvillous plasma membrane vesicles. In the SWS, alkaline phosphatase mRNA was measured using Nanostring. Alkaline phosphat

SUBMITTER: Hirschmugl B 

PROVIDER: S-EPMC6173293 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature