Intestinal epithelial Notch-1 protects from colorectal mucinous adenocarcinoma.

ABSTRACT: Increasing evidence links Notch-1 signaling with the maintenance of intestinal architecture and homeostasis. Dysfunction in the common Notch-1 pathway transcription factor recombinant binding protein suppressor of hairless (RBP-J) is associated with loss of epithelial barrier integrity and aberrant conversion of proliferative crypt cells into goblet cells. Furthermore, we have recently discovered that epithelial Notch-1 is indispensable in bridging innate and adaptive immunity in the gut and is required for supporting protective epithelial pro-inflammatory responses. Yet, the epithelial specific function of Notch-1 in intestinal tumorigenesis remains unknown. We generated Villin-Cre/Notch-1 ^fl/fl (VN ^-/- ) mice that are selectively deficien

SUBMITTER: Dunkin D 

PROVIDER: S-EPMC6173356 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature