Candida albicans Sfl1/Sfl2 regulatory network drives the formation of pathogenic microcolonies.

ABSTRACT: Candida albicans is an opportunistic fungal pathogen that can infect oral mucosal surfaces while being under continuous flow from saliva. Under specific conditions, C. albicans will form microcolonies that more closely resemble the biofilms formed in vivo than standard in vitro biofilm models. However, very little is known about these microcolonies, particularly genomic differences between these specialized biofilm structures and the traditional in vitro biofilms. In this study, we used a novel flow system, in which C. albicans spontaneously forms microcolonies, to further characterize the architecture of fungal microcolonies and their genomics compared to non-microcolony conditions. Fungal microcolonies arose from radially branching filamentous hyphae that increasingly intertwined with on

SUBMITTER: McCall AD 

PROVIDER: S-EPMC6173444 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature