Sex Differences in Genetic Associations With Longevity.

ABSTRACT:

Importance

Sex differences in genetic associations with human longevity remain largely unknown; investigations on this topic are important for individualized health care.

Objective

To explore sex differences in genetic associations with longevity.

Design setting and participants

This population-based case-control study used sex-specific genome-wide association study and polygenic risk score (PRS) analyses to examine sex differences in genetic associations with longevity. Five hundred sixty-four male and 1614 female participants older than 100 years were compared with a control group of 773 male and 1526 female individuals aged 40 to 64 years. All were Chinese Longitudinal Healthy Longevity Study participants with Han ethnicity who were recruited in 1998 and 2008 to 20

SUBMITTER: Zeng Y 

PROVIDER: S-EPMC6173523 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature