Fast Open Modification Spectral Library Searching through Approximate Nearest Neighbor Indexing.

ABSTRACT: Open modification searching (OMS) is a powerful search strategy that identifies peptides carrying any type of modification by allowing a modified spectrum to match against its unmodified variant by using a very wide precursor mass window. A drawback of this strategy, however, is that it leads to a large increase in search time. Although performing an open search can be done using existing spectral library search engines by simply setting a wide precursor mass window, none of these tools have been optimized for OMS, leading to excessive runtimes and suboptimal identification results. We present the ANN-SoLo tool for fast and accurate open spectral library searching. ANN-SoLo uses approximate nearest neighbor indexing to speed up OMS by selecting only a limited number of the most relevant li

SUBMITTER: Bittremieux W 

PROVIDER: S-EPMC6173621 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature