Ganglionic Antibody Level as a Predictor of Severity of Autonomic Failure.

ABSTRACT:

Objective

To assess antibody level as a test of autonomic failure (AF) associated with ganglionic nicotinic acetylcholine receptor antibody (AChR-Ab) autoimmunity.

Patients and methods

We searched the Mayo Clinic laboratory database of 926 ganglionic AChR-Ab-seropositive patients seen at our institution between October 1, 1997, and April 1, 2015, for initial level of 0.05 nmol/L or higher and contemporaneous autonomic reflex screen (standardized evaluation of adrenergic, cardiovagal, and sudomotor functions) from which Composite Autonomic Scoring Scale (CASS) scores could be calculated.

Results

Of 289 patients who met inclusion criteria, 163 (56.4%) were women, median age was 54 years (range, 10-87 years), median antibody level was 0.11 nmol/L (range, 0.05-22.10 nmol/

SUBMITTER: Cutsforth-Gregory JK 

PROVIDER: S-EPMC6173625 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature