A Jagged 1-Notch 4 molecular switch mediates airway inflammation induced by ultrafine particles.

ABSTRACT:

Background

Exposure to traffic-related particulate matter promotes asthma and allergic diseases. However, the precise cellular and molecular mechanisms by which particulate matter exposure acts to mediate these effects remain unclear.

Objective

We sought to elucidate the cellular targets and signaling pathways critical for augmentation of allergic airway inflammation induced by ambient ultrafine particles (UFP).

Methods

We used in vitro cell-culture assays with lung-derived antigen-presenting cells and allergen-specific T cells and in vivo mouse models of allergic airway inflammation with myeloid lineage-specific gene deletions, cellular reconstitution approaches, and antibody inhibition studies.

Results

We identified lung alveolar macrophages (AM) as the key c

SUBMITTER: Xia M 

PROVIDER: S-EPMC6173656 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature