Ontology highlight
ABSTRACT: Background
In the phase 3 METEOR trial, cabozantinib improved progression-free survival (PFS), objective response rate (ORR), and overall survival (OS) versus everolimus in patients with advanced renal cell carcinoma (RCC), after prior antiangiogenic therapy.Methods
Outcomes were evaluated for subgroups defined by prior therapy with sunitinib or pazopanib as the only prior VEGFR inhibitor, or prior anti-PD-1/PD-L1 therapy.Results
For the prior sunitinib subgroup (N = 267), median PFS for cabozantinib versus everolimus was 9.1 versus 3.7 months (HR 0.43, 95% CI 0.32-0.59), ORR was 16% versus 3%, and median OS was 21.4 versus 16.5 months (HR 0.66, 95% CI 0.47-0.93). For the prior pazopanib subgroup (N = 171), median PFS for cabozantinib versus everolimus was 7.4 versus 5.1 months (HR 0.67, 95% CI 0.45-0.99), ORR was 19% versus 4%, and median OS was 22.0 versus 17.5 months (HR 0.66, 95% CI 0.42-1.04). For prior anti-PD-1/PD-L1 therapy (N = 32), median PFS was not reached for cabozantinib versus 4.1 months for everolimus (HR 0.22, 95% CI 0.07-0.65), ORR was 22% versus 0%, and median OS was not reached versus 16.3 months (HR 0.56, 95% CI 0.21-1.52).Conclusions
Cabozantinib was associated with improved clinical outcomes versus everolimus in patients with advanced RCC, irrespective of prior therapy, including checkpoint inhibitor therapy.
SUBMITTER: Powles T
PROVIDER: S-EPMC6173766 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Powles Thomas T Motzer Robert J RJ Escudier Bernard B Pal Sumanta S Kollmannsberger Christian C Pikiel Joanna J Gurney Howard H Rha Sun Young SY Park Se Hoon SH Geertsen Poul F PF Gross-Goupil Marine M Grande Enrique E Suarez Cristina C Markby David W DW Arroyo Alan A Dean Mark M Choueiri Toni K TK George Daniel D
British journal of cancer 20180910 6
<h4>Background</h4>In the phase 3 METEOR trial, cabozantinib improved progression-free survival (PFS), objective response rate (ORR), and overall survival (OS) versus everolimus in patients with advanced renal cell carcinoma (RCC), after prior antiangiogenic therapy.<h4>Methods</h4>Outcomes were evaluated for subgroups defined by prior therapy with sunitinib or pazopanib as the only prior VEGFR inhibitor, or prior anti-PD-1/PD-L1 therapy.<h4>Results</h4>For the prior sunitinib subgroup (N = 267) ...[more]