Dynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment.

ABSTRACT: The initiation of heterogeneity within a population of phenotypically identical progenitors is a critical event for the onset of morphogenesis and differentiation patterning. Gap junction communication within multicellular systems produces complex networks of intercellular connectivity that result in heterogeneous distributions of intracellular signaling molecules. In this study, we investigate emergent systems-level behavior of the intercellular network within embryonic stem cell (ESC) populations and corresponding spatial organization during early neural differentiation. An agent-based model incorporates experimentally-determined parameters to yield complex transport networks for delivery of pro-differentiation cues between neighboring cells, reproducing the morphogenic trajectories duri

SUBMITTER: Glen CM 

PROVIDER: S-EPMC6173785 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature