Oral mucositis associated with anti-EGFR therapy in colorectal cancer: single institutional retrospective cohort study.

ABSTRACT:

Background

Chemotherapy-induced oral mucositis impairs the quality of life. The difference in severity of oral mucositis between different anti-epidermal growth factor receptor (EGFR) antibodies combined with cytotoxic drugs in colorectal cancer is unclear. The aim of this study was to investigate the differences in oral mucositis between panitumumab (Pmab) and cetuximab (Cmab) combined with 5-fluorouracil (5-FU).

Methods

We conducted a retrospective cohort study. A total of 75 colorectal cancer outpatients treated with an anti-EGFR antibody combined with FOLFOX, FOLFIRI, or 5-FU/leucovorin as the first- to third-line treatment were included. The primary endpoint was the incidence of grade 2-3 oral mucositis. The secondary endpoint was the time to onset of oral mucositis. We

SUBMITTER: Dote S 

PROVIDER: S-EPMC6173836 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature