An odorant receptor from Anopheles sinensis in China is sensitive to oviposition attractants.

ABSTRACT:

Background

Anopheles sinensis is an important vector for the spread of malaria in China. Olfactory-related behaviours, particularly oviposition site seeking, offer opportunities for disrupting the disease-transmission process.

Results

This is the first report of the identification and characterization of AsinOrco and AsinOR10 in An. sinensis. AsinOrco and AsinOR10 share 97.49% and 90.37% amino acid sequence identity, respectively, with related sequences in Anopheles gambiae. A functional analysis demonstrated that AsinOrco- and AsinOR10-coexpressing HEK293 cells were highly sensitive to 3-methylindole, but showed no significant differences in response to other test odorants when compared to DMSO.

Conclusions

AsinOrco was characterized as a new member of the Orco ortho

SUBMITTER: Liu H 

PROVIDER: S-EPMC6173891 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature