Genome-wide association study identifies loci and candidate genes for non-idiopathic pulmonary hypertension in Eastern Chinese Han population.

ABSTRACT:

Background

Pulmonary hypertension (PH) is a rare disease characterized by proliferation and occlusion of small pulmonary arterioles, which has been associated with a high mortality rate. The pathogenesis of PH is complex and incompletely understood, which includes both genetic and environmental factors that alter vascular structure and function.

Methods

Thus we aimed to reveal the potential genetic etiology of PH by targeting 143 tag SNPs of 14 candidate genes. Totally 208 individuals from Chinese Han population were enrolled in the present study, including 109 non-idiopathic PH patients and 99 healthy controls.

Results

The data revealed that 2 SNPs were associated with PH overall susceptibility at p < 3×10^- 4 after Bonferroni correction. The top hit was rs

SUBMITTER: Yin C 

PROVIDER: S-EPMC6173928 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature