Cancer phenotype in myotonic dystrophy patients: Results from a meta-analysis.

ABSTRACT:

Introduction

Recent studies have provided evidence that patients with myotonic dystrophy (DM) are at excess risk of cancer. However, inconsistencies regarding affected anatomic sites persist.

Methods

We performed a meta-analysis of cancer risk in DM, searching among studies published between January 1, 1990 and December 31, 2016. Eligible studies were full reports of DM cohorts with site-specific risks.

Results

The analysis included 5 studies, comprising 2,779 patients. Risk estimates for cancers of the endometrium and cutaneous melanoma were reported in all studies. The pooled standardized incidence ratio (pSIRs) for endometrial cancer was 7.48 (95% confidence interval [CI] 4.72-11.8) and for cutaneous melanoma was 2.45 (95% CI 1.31-4.58). Among cancers reported in 4

SUBMITTER: Emparanza JI 

PROVIDER: S-EPMC6173974 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature