Quantitative evaluation of tau PET tracers ¹⁸F-THK5351 and ¹⁸F-AV-1451 in Alzheimer's disease with standardized uptake value peak-alignment (SUVP) normalization.

ABSTRACT:

Purpose

Off-target binding in the reference region is a challenge for recent tau tracers ¹⁸F-AV-1451 and ¹⁸F-THK5351. The conventional standardized uptake value ratio (SUVR) method relies on the average uptake from an unaffected tissue sample, and therefore is susceptible to biases from off-target binding as well as variability among individuals in the reference region. We propose a new method, standardized uptake value peak-alignment (SUVP), to reduce the bias of the SUVR, and improve the quantitative assessment of tau deposition.

Methods

The SUVP normalizes uptake values by their mode and standard deviation. Instead of using a reference region, the SUVP derives the contrast from unaffected voxels over the whole brain. Using SUVP and SUVR methods, we e

SUBMITTER: Chen J 

PROVIDER: S-EPMC6174003 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature