Tumor-derived exosomes induce N2 polarization of neutrophils to promote gastric cancer cell migration.

ABSTRACT:

Background

Exosomes are extracellular vesicles that mediate cellular communication in health and diseases. Neutrophils could be polarized to a pro-tumor phenotype by tumor. The function of tumor-derived exosomes in neutrophil regulation remains unclear.

Methods

We investigated the effects of gastric cancer cell-derived exosomes (GC-Ex) on the pro-tumor activation of neutrophils and elucidated the underlying mechanisms.

Results

GC-Ex prolonged neutrophil survival and induced expression of inflammatory factors in neutrophils. GC-Ex-activated neutrophils, in turn, promoted gastric cancer cell migration. GC-Ex transported high mobility group box-1 (HMGB1) that activated NF-κB pathway through interaction with TLR4, resulting in an increased autophagic response in neutrophi

SUBMITTER: Zhang X 

PROVIDER: S-EPMC6174070 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature