Classifying Included and Excluded Exons in Exon Skipping Event Using Histone Modifications.

ABSTRACT: Alternative splicing (AS) not only ensures the diversity of gene expression products, but also closely correlated with genetic diseases. Therefore, knowledge about regulatory mechanisms of AS will provide useful clues for understanding its biological functions. In the current study, a random forest based method was developed to classify included and excluded exons in exon skipping event. In this method, the samples in the dataset were encoded by using optimal histone modification features which were optimized by using the Maximum Relevance Maximum Distance (MRMD) feature selection technique. The proposed method obtained an accuracy of 72.91% in 10-fold cross validation test and outperformed existing methods. Meanwhile, we also systematically analyzed the distribution of histone modificatio

SUBMITTER: Chen W 

PROVIDER: S-EPMC6174203 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature