RSV vs. rhinovirus bronchiolitis: difference in nasal airway microRNA profiles and NFκB signaling.

ABSTRACT: BackgroundAlthough rhinovirus infection is associated with increased risks of acute and chronic respiratory outcomes during childhood compared with respiratory syncytial virus (RSV), the underlying mechanisms remain unclear. We aimed to determine the differences in nasal airway microRNA profiles and their downstream effects between infants with rhinovirus and RSV bronchiolitis.MethodsAs part of a multicenter cohort study of infants hospitalized for bronchiolitis, we examined nasal samples obtained from 16 infants with rhinovirus and 16 infants with RSV. We tested nasal airway samples using microarrays to profile global microRNA expression and determine the predicted regulation of targeted transcripts. We also measured gene expression and cytokines for NFκB pathway components.ResultsBetween

SUBMITTER: Hasegawa K 

PROVIDER: S-EPMC6174252 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature