Naringenin Modifies the Development of Lineage-Specific Effector CD4⁺ T Cells.

ABSTRACT: Disrupted balance in the lineages of CD4⁺ T cell subsets, including pro-inflammatory T helper (Th) cells and anti-inflammatory regulatory T cells (Treg), is a primary pathogenic factor for developing autoimmunity. We have found that this immunomodulatory effect of naringenin on effector T cells and T-cell mediated experimental autoimmune encephalomyelitis (EAE). We therefore explored the effects of naringenin on the development of different effector CD4⁺ T cells. Naïve CD4⁺ T cells were differentiated under respective Th1, Th2, Th17, and Treg polarizing conditions with naringenin. Percent populations of each differentiated CD4⁺ T cell subsets were determined and the corresponding regulating pathways were investigated as underlying mechanisms. Nar

SUBMITTER: Wang J 

PROVIDER: S-EPMC6174281 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature