Programmed death ligand 1 expression in human intrahepatic cholangiocarcinoma and its association with prognosis and CD8⁺ T-cell immune responses.

ABSTRACT:

Background

Agents targeting the programmed death ligand 1 (PD-L1)/programmed death receptor 1 immune checkpoint exhibited promising clinical outcomes in a variety of malignant tumors, including intrahepatic cholangiocarcinoma (ICC). However, the relationship between PD-L1 expression and CD8⁺ T-cell immune responses is not well defined in ICC.

Patients and methods

We investigated PD-L1 expression immunohistochemistry in formalin-fixed, paraffin-embedded tissues from 192 ICC patients undergoing curative resection and correlated our results with the clinicopathologic features and prognosis. We also quantified CD8⁺ T-cell infiltration in ICC specimens and evaluated the relationship between PD-L1 expression and CD8⁺ T-cell infiltration. After incu

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC6174308 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature