Physiological Responses to Swimming-Induced Exercise in the Adult Zebrafish Regenerating Heart.

ABSTRACT: Exercise promotes a set of physiological responses known to provide long-term health benefits and it can play an important role in cardioprotection. In the present study, we examined cardiac responses to exercise training in the adult zebrafish and in the context of cardiac regeneration. We found that swimming-induced exercise increased cardiomyocyte proliferation and that this response was also found under regenerating conditions, when exercise was performed either prior to and after ventricular cryoinjury (CI). Exercise prior to CI resulted in a mild improvement in cardiac function and lesion recovery over the non-exercise condition. Transcriptomic profiling of regenerating ventricles in cryoinjured fish subjected to exercise identified genes possibly involved in the cardioprotective eff

SUBMITTER: Rovira M 

PROVIDER: S-EPMC6174316 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature