Laparoscopic cholecystectomy versus percutaneous catheter drainage for acute cholecystitis in high risk patients (CHOCOLATE): multicentre randomised clinical trial.

ABSTRACT:

Objective

To assess whether laparoscopic cholecystectomy is superior to percutaneous catheter drainage in high risk patients with acute calculous cholecystitis.

Design

Multicentre, randomised controlled, superiority trial.

Setting

11 hospitals in the Netherlands, February 2011 to January 2016.

Participants

142 high risk patients with acute calculous cholecystitis were randomly allocated to laparoscopic cholecystectomy (n=66) or to percutaneous catheter drainage (n=68). High risk was defined as an acute physiological assessment and chronic health evaluation II (APACHE II) score of 7 or more.

Main outcome measures

The primary endpoints were death within one year and the occurrence of major complications, defined as infectious and cardiopulmonary complicati

SUBMITTER: Loozen CS 

PROVIDER: S-EPMC6174331 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature