Data Analytics from Enroll-HD, a Global Clinical Research Platform for Huntington's Disease.

ABSTRACT:

Background

The study of complex neurodegenerative diseases is moving away from hypothesis-driven biological methods toward large scale multimodal approaches, requiring standardized collaborative efforts. Enroll-HD exemplifies such an integrated clinical research platform, designed and implemented to meet the research and clinical needs of Huntington's disease (HD). The aim of this study was to describe the unique organization of Enroll-HD and report baseline data analyses of its core study.

Methods

The Enroll-HD platform incorporates electronic data capture, biosampling, and a longitudinal observational study spanning four continents (ClinicalTrials.gov Identifier: NCT01574053). The primary study population includes HD gene expansion carriers (HDGECs; CAG expansion ≥36), sub

SUBMITTER: Landwehrmeyer GB 

PROVIDER: S-EPMC6174428 | biostudies-literature | 2017 Mar-Apr

REPOSITORIES: biostudies-literature