Body Mass Index Decline Is Related to Spinocerebellar Ataxia Disease Progression.

ABSTRACT:

Background

Spinocerebellar ataxias (SCAs) are dominantly inherited, progressive ataxia disorders. Disease progression could be preceded by weight loss.

Objectives

We aimed to study the course of weight loss in patients who had the most common SCAs (SCA1, SCA2 SCA3, and SCA6). Additional objectives were to identify subgroups of weight evolution, to determine the factors influencing these evolutions, and to assess the impact of these evolutions on disease progression.

Methods

In total, 384 patients from the EUROSCA prospective cohort study were analyzed who had SCA1, SCA2, SCA3, or SCA6 and at least 3 measurements of weight. Age was used as a time scale. Clinical outcomes were body mass index (BMI) and the Scale for the Assessment and Rating Ataxia (SARA), with scores r

SUBMITTER: Diallo A 

PROVIDER: S-EPMC6174467 | biostudies-literature | 2017 Sep-Oct

REPOSITORIES: biostudies-literature