Survival, Mortality, Causes and Places of Death in a European Huntington's Disease Prospective Cohort.

ABSTRACT:

Background

Huntington's disease (HD) is a rare and fatal inherited genetic disorder characterized by progressive motor, cognitive, and behavioral impairment. It leads to premature death, but data regarding advanced-stage disease are scarce. We sought to determine HD-associated survival, mortality, and causes and places of death.

Methods

Data from the European HD Network prospective study (REGISTRY) collected from 2001 through 2013 were used, including the Unified Huntington's Disease Rating Scale and death report forms. Group comparisons were performed using the t test or the χ² test. Survival analyses were computed through Kaplan-Meier estimates of median survival. All tests were 2-sided with a significance level of P = 0.05.

Results

I

SUBMITTER: Rodrigues FB 

PROVIDER: S-EPMC6174515 | biostudies-literature | 2017 Sep-Oct

REPOSITORIES: biostudies-literature