Genes, maternal smoking, and the offspring brain and body during adolescence: design of the Saguenay Youth Study.

ABSTRACT: The search for genes of complex traits is aided by the availability of multiple quantitative phenotypes collected in geographically isolated populations. Here we provide rationale for a large-scale study of gene-environment interactions influencing brain and behavior and cardiovascular and metabolic health in adolescence, namely the Saguenay Youth Study (SYS). The SYS is a retrospective study of long-term consequences of prenatal exposure to maternal cigarette smoking (PEMCS) in which multiple quantitative phenotypes are acquired over five sessions (telephone interview, home, hospital, laboratory, and school). To facilitate the search for genes that modify an individual's response to an in utero environment (i.e. PEMCS), the study is family-based (adolescent sibships) and is carried out in

SUBMITTER: Pausova Z 

PROVIDER: S-EPMC6174527 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature