Vaccination with chemically attenuated Plasmodium falciparum asexual blood-stage parasites induces parasite-specific cellular immune responses in malaria-naive volunteers: a pilot study.

ABSTRACT:

Background

The continuing morbidity and mortality associated with infection with malaria parasites highlights the urgent need for a vaccine. The efficacy of sub-unit vaccines tested in clinical trials in malaria-endemic areas has thus far been disappointing, sparking renewed interest in the whole parasite vaccine approach. We previously showed that a chemically attenuated whole parasite asexual blood-stage vaccine induced CD4⁺ T cell-dependent protection against challenge with homologous and heterologous parasites in rodent models of malaria.

Methods

In this current study, we evaluated the immunogenicity and safety of chemically attenuated asexual blood-stage Plasmodium falciparum (Pf) parasites in eight malaria-naïve human volunteers. Study participants received

SUBMITTER: Stanisic DI 

PROVIDER: S-EPMC6174572 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature