The MSOAC approach to developing performance outcomes to measure and monitor multiple sclerosis disability.

ABSTRACT:

Background

The Multiple Sclerosis Outcome Assessments Consortium (MSOAC) was formed by the National MS Society to develop improved measures of multiple sclerosis (MS)-related disability.

Objectives

(1) To assess the current literature and available data on functional performance outcome measures (PerfOs) and (2) to determine suitability of using PerfOs to quantify MS disability in MS clinical trials.

Methods

(1) Identify disability dimensions common in MS; (2) conduct a comprehensive literature review of measures for those dimensions; (3) develop an MS Clinical Data Interchange Standards Consortium (CDISC) data standard; (4) create a database of standardized, pooled clinical trial data; (5) analyze the pooled data to assess psychometric properties of candidate measure

SUBMITTER: LaRocca NG 

PROVIDER: S-EPMC6174619 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature